Hi Everyone. I have a new book releasing!
This is the 6th paperback volume of my Table of Animals Project, detailing the Hemichordates, Echinoderms ( starfish), Lampreys, Sharks, and Bony Fish. It is a lovely work, and I hope you all enjoy it.
You can purchase the physical book here, and the ebook here.
It was also most lovely to travel accross Canada this week to begin presenting some of my ideas. I was in Saskatoon to present on ideas of immunity and vitality, and in Montreal to present briefly on the relationship of the butterflies and plants and Michal Yakir’s teaching. This was particularly wonderful, and Michal inspired my own work with animals. We got along wonderfully, had a lovely trituration after the seminar, and then agreed to do some collaborative work. HEre is a phot of us holding each other’s books!
Anyway, I hope you Enjoy the books! Please do read them, and tell me what you think!
Take care of yourselves!
I hope you all had an excellent Naturopathic Medicine week in 2019!
As always, I will conclude the week with a blog post detailing the research into Naturopathic Medicine. Each year seems to bring new advances, which I am immensely grateful for. To begin with, we should discuss Naturopathic regulation globally, something that the World Naturopathic Federation has done wonderfully in the following paper. One of my own teachers, Dr. Mike Prytula, ND, has also made a lovely introductory video on Naturopathic Medicine.
To begin with, two reviews of all clinical trials on Naturopathic medicine have been conducted. The first was done in 2015, and found clinical trials on 13 conditions, finding statistically significant results in 10 of them. A second review conducted in 2019 found 33 trials, with Naturopathic medicine being found effective in pain, cardiovascular illness, type 2 diabetes, PCOS, depression and anxiety.
A newer review was also performed, specifically in regard to side effects of Naturopathic medicine and surgical practice. The reviewers found a number of potential benefits naturopathic treatment could have in relation to surgery that demand further study, and no reports of serious side effects present.
Naturopathic care in Cardiovascular disease was recently examined in a clinical trial. 246 postal workers received Naturopathic care (207 completed the study) in addition to normal family medicine from their MD. Lab chemistry was taken before and after Naturopathic care,and their risk of a major cardiovascular even was computed using the Framingham Risk Score method of computing the likelihood of a Cardiovascular event, and the Adult Risk Panel III to compute the prevalence of metabolic syndrome. One group in the study received Naturopathic care plus normal medical care, and another received only normal medical care. In this study a highly significantly reduced risk of a major cardiovascular event (risk reduction in control group of 10.81, risk in Naturopathic group of 7.74% for a reduction of 3.07%) and a reduction of metabolic syndrome (48.48% control group, 31.58% Naturopathic group for a reduction 16.9%).Naturopathic care in Cardiovascular disease was recently examined in a clinical trial. 246 postal workers received Naturopathic care (207 completed the study) in addition to normal family medicine from their MD. Lab chemistry was taken before and after Naturopathic care,and their risk of a major cardiovascular even was computed using the Framingham Risk Score method of computing the likelihood of a Cardiovascular event, and the Adult Risk Panel III to compute the prevalence of metabolic syndrome. One group in the study received Naturopathic care plus normal medical care, and another received only normal medical care. In this study a highly significantly reduced risk of a major cardiovascular event (risk reduction in control group of 10.81, risk in Naturopathic group of 7.74% for a reduction of 3.07%) and a reduction of metabolic syndrome (48.48% control group, 31.58% Naturopathic group for a reduction 16.9%).
This data was further analyzed in another paper for the economic impact of Naturopathic treatment. The above trial resulted in (corresponding to a 3.3% decreased risk of a Cardiovascular event) in a savings of $1138 in costs to society and $1187 in employer costs per year of Naturopathic treatment. The cost savings of livelong Naturopathic care that could be speculated on based on this remain staggering.
In response to this trial, this MD in CMAJ endorsed the idea of delegating some aspects of Cardiovascular care from Medical to Naturopathic Doctors. Many MDs would oppose this, but a significant minority of our Allopathic cousins would gladly cooperate with us in patient management.
Another Clinical trial on the Naturopathic treatment of rotator cuff tendonitis was recently published. In it, a group of postal workers with diagnosed rotator cuff tendontis received either a standard set of physiotherapy exercises to do on their own (an approach not unlike that which many MDs in family practice will use before a physiotherapy referral) as well as a matched placebo. Pain was measured using Shoulder pain and disability index scores, visual analogue pain score, Short form 36, and MYMOP. 87% of participants completed 8 weeks of treatment, SPADI scores decreased by 54.5% (p<0.0001) in the Naturopathic care group and 18% (p<0.0241) in the Exercise group. All measures showed significant differences in favor of Naturopathic care, with SPADI showing a difference probability of <0.0001 and no major adverse outcomes reported.
In a similar trial 75 postal employees with back pain greater than 6 weeks duration were given either Naturopathic medicine or standardized exercises ( again similar to what they might recieve at an MD practice) for 12 weeks. Progress was measured using the Oswestry disability questionaire, as well as the SF-36, lower back range of motion, weight loss and BMI. 92% completed at least 8 weeks of treatment. Back pain reduced significantly in the Naturopathic group (-6.92 on Oswestry, p<0.0001) and all other measure improved significantly as well.
The above trial was analyzed for economic impact. In the analysis, employees experienced 9.4 more perfect health days and reduced societal ( read employer) costs of $1212 per participant over the course of the study. The intervention cost $154 per day, compared with lost productivity costs of $178 per day, representing a return on investment of7.9%. Individuals participating saved $1096 each. Again this was from a single course of treatment. Imagine the cost savings applied society wide, particularly in countries like Canada with socialized medicine.
Another small Indian study showed significant improvements in PEFR, VC, FVC, FEV1, FEV/FEC%, MVV< ESR and Absolute Eosinophil count in Asthma patients undergoing a Naturopathic and Yogic treatment regimen.
In another study, patient outcomes from Naturopathic and Allopathic medical practices were compared in the treatment of menopausal symptoms. Consistent with other research, Naturopathic patients reported higher income, lower rates of smoking, higher rates of exercise, but interestingly, greater rates of fatigue, insomnia and hot flashes. Both patient groups resulted in improvements in anxiety, hot flashes, vaginal dryness and menstrual changes. Significantly better results were found in insomnia and fatigue.
One study was done on patients with Autism, 67 patients ranging from 3-58 years were given supplementation, with additional naturopathic treatments, such as enzymes, carnitine, epsom salts baths and a diet free of gluten, casein and soy. Lab results show a significant improvement of blood nutrient levels, and nonverbal IQ and autism symptoms also significantly improved.
Another study examines Polycystic ovarian syndrome patients who had undergone a Naturopathic and Yogic regimen for 12 weeks. 25 patients were given the intervention, while 25 others were placed on a wait list. Significant changes were observed in ovarian morphology and body measurements.
Recent Indian research has focused on a number of areas of integration of Naturopathic medicine and conventional care. This paper reviews the multiple ways many Naturopathic agents can aid in modulating cell signalling pathways in cancer. Another paper shows a similar conclusion, with Natural compounds showing great promise in decreasing resistance to one method of cell self destruction in cancers.
Much recent research has focused on the types of patients Naturopathic Doctors see. In one recent study a survey of 300483 visits to a Naturopathic teaching clinic was examined. It was found that Naturopathic clinics saw a similar range of problems to other primary care practices, that patients paid out of pocket more (unsurprisingly) and that Naturopathic clinics offered discounted care far more often.
Another recent study discussed characteristics of Pediatric patients coming to CCNM, a Naturopathic college in Toronto. Furthermore, a cross section of Naturopathic patients as a whole at CCNM was done, showing the incredibly wide variety of issues people come to Naturopathic Doctors with.
Another fascinating direction of research has emerged in the applications of Public health models of research to Naturopathic care, rather than more allopathic models a potential research enterprise with much potential. Another study measured the characteristics of rural Naturopathic practice in Australia, showing the important role played by naturopaths in the provision of underserved rural populations. Another study showed a high level of patient and staff satisfaction resulting from integration of Naturopathic medicine into an acute care hospital.
Perhaps most intriguingly in our survey of research is this paper, published in the Indian Journal of Medical Ethics. India is in the slow process of constructing a healthcare system of Universal coverage (often jokingly termed Modicare after the Indian Prime Minister Narendera Modi). Unlike in Countries such as Canada which have long traditions of public medicine that were built during the low point of Holistic medicine, in the 1960s, India likely will be including all systems of medicine in it’s public scheme, along with allopathic care. AYUSH is the term in India used for such systems, including Ayurveda, Therapeutic Yoga, Unani, Sidda, Homeopathy and Naturopathy. The above mentioned paper examined the AYUSH systems in light of a report on the Principles of Universal Care produced by the Planning Commission of India. In that paper, the authors conclude that not only does AYUSH meet the standards the India government wishes to see in it’s Universal system, they would actually further it’s goals more effectively in many cases than Allopathic care alone would be able to.
Finally, there is a free documentary showing Naturopathic medicine being practiced in India, to fully scope, in in-patient facilities. I encourage you to watch it. It is my hope that the example of India in medical equality and non discrimination will be followed by Canada and other Western countries, giving all citizens the potential for access to the benefits of Naturopathic Treatment.
Happy Naturopathic Medicine Week Everyone!
Hi Everyone. Apologies for not writing earlier. I am quite occupied by the writing of a new book on Blockages to healing, and a few other things.
But I did find time to write another article on the evidence behind Homeopathy is response to a particularly horrendous one published recently. It’s on my Publications page, and you can also find a link here.
Hope you all are doing well. I will again be doing my annual compilation of Naturopathic Research for Naturopathic Medicine week, which starts May 13th!
Hi Everyone.
So, in cooperation with the students of my alma mater, the Canadian College of Naturopathic Medicine, and the filmmaker Ananda More of the film Magic Pills, as well as researcher and Homeopath David Brulé, I appeared on a film panel following a screening of Magic Pills during Vitalism Week at CCNM. This panel was recorded, and is available below. I would love to hear what you think about it.
Apparently I was funny.
You can access the panel video here.
Hi Everybody. I do apologize for my lack of posting lately. I have been consumed lately with the writing of a rebuttal to a tremendously bad article on Naturopathic Education, and in the casework for my DHANP certification from the Homeopathic Academy of Naturopathic Physicians. My case writeups totalled about 70 pages so far, so it took up quite a bit of my time!
In addition to this, I also completed the editing of a book. Two books of mine have been published in the last few months, and I decided to write a blog post about them!
The first book is the third volume of my Table of Animals Project. It focuses on the Nematodes and early Arthropods, including the Trilobites, Myriapods (Centipedes and Millipedes), Crustaceans, and Chelicerates (Spiders, Ticks, Scorpions and Horseshoe crabs). This book is the most upto date look at these remedies, and the first dicussion of many of these groups. The Nematodes had never been explored Homeopathically before, and the Trilobites, Crustaceans, and Myriapods had not been examined as a group before. The book can be purchased here.
The second book is a continuation of the first, an exploartion of the Insect remedies within Homeopathy. I was only expecting a few remedies to be available, but this book rapidly became more than 300 pages long, and so needed it’s own volume. This is the most detailed exploration of the Insect remedies available, containing two new triturations of my own. This book can be purchased here.
I have also added some of the triturations within my books as part of my publications page. The Triturations of these animals will be posted upto C4 on my publications page:
- Mnemiopsis macrydi (A Ctenophore)
- Stinernema Feltiae ( The first Nematode trituration in Homeopathy)
- Elrathia kingii (A Trilobite)
- Euphausia superba oleum ( Krill Oil)
- Ethmostigmus rubripes (A Centipede)
- Mesobuthus martensi ( A Scorpion)
- Drosophila (A Fruit Fly)
- Colias philodice (A Butterfly)
I hope you all enjoy these books and provings! More will be coming soon. Up next will be the Table of animals on the Fish, and my presentation at the Healing Skies Conference in Saskatoon in June!
Take care of yourselves!
Hi Everyone. I am just wishing you all a Happy Holidays, Merry Christmas and a lovely New Year.
This song always filled me with Joy, and I hope you all get a bit out of it as well!
Hi Everyone. So a great deal of disscussion has been conducted online about the scientific evaluation of Homeopathy. Given the recent emphasis on Evidence based Medicine, and it’s methods of evaluation, much of the recent discussion has focused on Randomised Controlled Clinical Trials which have generally been accepted as the best methods to evaluate clinicl interventions (although I would refer readers to Harris Coulter’s publication on the subject for a more full view).
In short, a Randomized Controlled Clinical Trial is an examination of the results of an intervention, performed on different, but theoretically identical, populations. The intervention should be indistinguishable, and the evaluation of the patients should be done in such a way that any human element, or analysis, is conducted without knowledge of which group of patients have received which intervention.
This type of study is designed very well for allopathic style interventions. It presumes that the intervention is singular, static, and does not require feedback after administered, ie., as many prescription drugs. Homeopathy is not well suited to this style of trial, without some significant adjustments, for a number of reasons.
- Finding the remedy is difficult. The process of remedy selection is a challenging process, involving the consideration of multiple factors, etiology, the mental emotional state, and of course, the eventual success of administration. The only way to determine whether a remedy was Homeopathic to a case is the patient responding to the remedy, that is, feedback. Feedback and dose adjustment
- Sensitivity to Homeopathic Remedies varies. Some individuals will aggravate from the lowest potencies of a remedy, others need higher potencies than normal. Many individuals fall somewhere in the middle of susceptibility to remedies. Finding a proper Homeopathic prescription involves finding not only the right remedy, but the right potency.
- Potency changes as patient’s course unfolds. Almost universally, when a successful remedy and potency is found, over time the patient will respond progressively less to repeated doses of that potency, eventually failing to respond whatsoever. At this point, a higher, more potentised preparation of the same remedy is required.
- Occasionally intercurrent remedies, or remedies addressing a specific issue or obstacle to cure, will become apparent. When this occurs, the case must be retaken, a new remedy or other intervention performed, and the older remedy stopped. Often the older remedy can be restarted after the particular inercurrent remedy has completed it’s work
- Remedies change, oftentimes a person will completely resolve their symptom complex with a given remedy, and then will no longer requiring it, either needing no remedy, or another suited to whatever picture emerges.
These traits of Homeopathic care each require detailed feedback and adjustments to therapy. This kind of adjustment is impossible in a placebo controlled setting.
Despite these problems, a number of methodological refinements have been made to the process of clinical trials which do make this method of examination more suited to the examination of Homeopathy.
- The first refinement is to have the Homeopathic practitioner select the remedy and do whatever process of feedback needed to settle on an effective remedy, then blind the patient as to whether or not they are receiving the remedy or placebo, and measure their condition under both placebo and verum. The best example of this style of trial is Heiner Frei’s excellent trial of ADHD. You can read this trial here. While this does not address remedies changing, intercurrents, or the need for increased potency, it is certainly an improvement.
- The second refinement is to pre select for patients who will respond to a particular remedy. The premier example of this type of trial is Peter Fisher’s older trial where patients who would match the symptoms of Rhus Tox were screened from a population, and administered the remedy. You can read this trial here. While this method also does not account for individual sensitivity to remedies, need for increased potencies, intercurrent remedies or remedies changing, it still is a good method.
- A third method is to use prescribers with high levels of accuracy, and have a big enough sample size that it becomes possible to demonstrate smaller improvements, which are the likely outcome with all of the methodological issues described above. Numerous example of these trials exist, but one can be found here.
Despite these issues, as Mathie has demonstrated in his famous 2014 paper, the overall picture of Clinical trial research into individualized Homeopathy as a whole is positive. Due to a lack of trials in Homeopathy, it is difficult to assess individual conditions with any great accuracy. However, a metanalysis has recently been performed with respect to Homeopathic treatment of depression. In it, the researchers found 18 studies, including two placebo controlled trials, both positive, and one with a low risk of bias. Overall the researchers concluded that while the evidence was promising, but that more high quality studies were needed, but that the safety profile was potentially excellent ( as compared with the Standard of care of antidepressants with thier numerous side effects and increased risk of suicide). As Homeopathy research increases in quantity and quality, these suggestions will be met, and numerous other conditions will be studied.
The common line of discussion against Homeopathy is that it lacks evidence. This is fundamentally untrue, and those who repeat it are either ignorant or being actively deceptive. As Mathie demonstrated, the overall trend of Individualized clinical trial data is positive, even if it requires higher quality studies to be absolutely definitive. Taking these methodological issues into consideration when designing clinical trials will result in trials more accurately reflecting Homeopathic practice, and will assist in us producing the good evidence which will likely not silence our critics, but will end any legitimate scientific debate about Homeopathy.
Hi Everyone!
So as many of you know, I have a very lively ( and occasionally snarky) twitter account, which can be found under the name @DrPaulND. As in any human endeavor on twitter, there is quite a bit of trolling and unpleasant discourse that occurs. However, being on twitter does give me a great deal of insight into current trends in the discourses of those ideologically opposed to Homeopathy and Naturopathic medicine.
As I detailed in a previous blog post, the most recent and most heavily propagandized systematic review on Homeopathy was the NHMRC review. Using Fake News Tactics, a number of groups promoted this report, despite it’s terrible methodology and numerous problems. Most tellingly, no skeptical organization has, to my knowledge, explored or even acknowledged these problems.
Rachel Roberts of the Homeopathy research institute describes the faults in the study in the following video.
These irregularities are summarized as follows (Taken from my previous blog on Homeopathy research)
- NHMRC did the review twice
- The first review, and even it’s existence, was not disclosed to the public
- the NHMRC, upon questioning, responded that the first review was low quality despite being conducted by the individual responsible for developing NHMRC’s guidelines on how to conduct evidence reviews
- FOI requests confirm that a member of NHMRC, Fred Mandelsohn, confirmed the first review to be high quality stating ““I am impressed by the rigor, thoroughness and systematic approach given to this evaluation [….] Overall, a lot of excellent work has gone into this review and the results are presented in a systematic, unbiased and convincing manner.”
- NHMRC stated their results were based on over 1800 studies, when in fact they were based on only 176
- NHMRC has used a method which has never been used in any other review, declaring that only trials of over 150 participants would be accepted, excluding the vast majority of high quality homeopathic trials, which due to lack of funding tend to be smaller, and despite the fact the NHMRC routinely conducts studies of less than 150 participants
- The above rules resulted in exclusion of 171 of 176 studies, leaving only 5 to be used as the basis of the study
- The chair of the second review, Peter Brooks, signed a conflict of interest form declaring himself “free from any association with any organization whose interests are either aligned or opposed to Homeopathy” when he was a member of the anti homeopathy lobby group “friends of science in medicine”
- The NHMRC review included no homeopaths or experts in Homeopathy research, despite the NHMRC guidelines requiring such an inclusion
As a result of these irregularities, Rachel made a complaint to the ombudsman of Australia on this report, which being a government agency, is accountable to the public. The Australian Ombudsman, who reviewed the complaint, found it of sufficient merit as to investigate it directly. They have proceeded to investigate this complaint since then, and according to Roberts, this investigation will soon reach a conclusion, as she discusses in this video.
This investigation has recently been maligned by a number of coordinated online campaigns. The skeptical community appears to have been spreading the rumour that this investigation has not, in fact occurred due to the large length of time since the making of the complaint. This is a complete lie. The ombudsman of Australia has very clear privacy policies, listed here. As is the case in most countries with protection of privacy legislation, information on ongoing investigations is held confidential until reports are issued.
The length of the investigation is indeed lengthy. However indeed, some investigations, particularily complex ones, often take months, as is mentioned in this FAQ on the Ombudsman’s website. Lengthy investigations are indeed not unprecedented, particularly in complex matters, as an investigation of a lengthy report in a contentious field would undoubtedly would be.
Secondly the complaints process is generally only communicated to the people in question who have started the complaint. Rachel Roberts, again, being that person, is the only person privy to that information, and her testimony on that subject is, as we have seen above, quite clear. The people spreading these rumours are not privy to the complaint process, and are spreading heresay in an attempt to discredit the fact that the Ombudsman found the complaint made by HRI to be of sufficient merit to warrant the Australian government investing it’s own resources in a very lengthy investigation into wrongdoing by NHMRC in this matter.
Furthermore, to add some extra spice to this already interesting set of circumstances, The Australian Senate recently questioned the NHMRC. One senator, Sterling Griff, questioned the department of health on the NHMRC review of Homeopathy. The answers were provided in writing and are available online see questions 214, 215, 261, 264, 268, 269, 270, 273, 274, and 275 ( And thank you so much to the website yourhealthyourchoice.com for this blog post which went into detail on this subject, who’s work I am largely repeating). While these answers will be discussed in future blogs, I encourage you to read them on your own.
The blog post by yourhealthyourchoice.com was quite succinct in detailing the inconsistencies in the NHMRC’s response to the Senator’s question 268 on the arbitrary limit of 150 per study. Both Question and answer are reproduced below:
Question:
The Homeopathy Review created a rule that trials with less than 150 participants were not ‘reliable’, meaning their results did not “warrant further consideration of their findings” (Information Paper, Appendix C). Does the NHMRC apply this rule to other trials it funds and/or reviews? If so, where else has this rule been applied and what internationally accepted scientific standards were used to authenticate it?
Answer:
Studies with less than 150 participants were not excluded from consideration in the evidence assessment. The Homeopathy Working Committee (HWC) deemed that, for the purposes of drafting evidence statements, the outcomes of studies with less than 150 participants were not sufficiently powered to reliably inform conclusions on the effectiveness of homeopathy to treat a particular clinical condition. NHMRC establishes expert working committees, such as the HWC, under section 39 of the NHMRC Act, to advise NHMRC on the methodology and parameters of evidence evaluation when developing health advice and guidelines. This is in line with international best practice for formulating evidence-based health advice. The HWC has expertise in evidence-based medicine, clinical trials and complementary medicine. There is no ruling as to the number of participants that is appropriate for a trial that applies for funding by NHMRC. Applications are selected for funding through a competitive peer review process. The grant review panel assesses the application against published criteria. Issues such as trial sample size, experimental design and the power are usually assessed under “scientific quality”. If, in the judgement of the expert assessors, the scientific quality is compromised by inadequate trial size, this will be reflected in the score for that assessment criterion.”
This answer is remarkable in it’s deceptiveness. As shown by the Your Health blog, the question was never actually answered. NHMRC, yet again, did not specify why the cutoff of 150 was chosen, and failed to justify it. This is particularily ironic in that NHMRC itself regularily funds and conducts trials of less than 150, as YourHealthYourChoice demonstrated.
Secondly, The answer incorrectly states that the sample size of 150 was not used to exclude trials. However, the NHMRC information paper on page 34-35 and Optum overview report appendices on page 275 both do confirm this. In effect NHMRC specifically crafted it’s protocol to exclude unreliable studies, and then defined, without justification, anything less than 150 as unreliable, reducing massively the pool of studies that they could draw upon to make their conclusion.
Furthermore, their answers to the Senator Griff concealed this from the government, either deliberately, or through ignorance on part of the answering person.
This act of deception, more than anything else, likely explains the length of this investigation. It cannot be expected that a body that went to such length to pervert science to create a given outcome will be particularly with a government investigation of their practices and, dare I say it, motivations for doing so.
I encourage everyone to read the following blog post going into great detail
NHMRC under scrutiny in the Senate – Full and accurate answers not provided
Hi Everyone. I have a few new releases to share!
The first is my latest E-book! This book is part of the Table of Animals Series and covers the early Ecdysozoa, the Nematodes and early Arthropods, the Trilobites, Crustaceans and Myriaopods. It is an ebook, and will be published as a paperback, hopefully sometime in September. This book can be purchased here.
I have also made a few videos on making remedies. The first, on how to graft a remedy, is below:
The second on how to make an H potency of a remedy, or how to potentize a remedy at home, is below:
To begin with, the blog post must be acknowledged as being a mere snapshot of a very vast field. I apologize for the incompleteness, but an tire book would be required for a full understanding, and I do suspect that it would be quickly out of date.
As some background, Homeopathy has a long history of clinical trials, and testing in humans. These trials have always generated a great deal of contention, and it has always been disputed that the effect of Homeopathic interventions is due to the effect of the remedies. Other factors, such as the counseling, other lifestyle interventions recommended, and even the poor social skills of allopathic doctors in comparison have been suggested as the factors responsible. The most popular explanation has been the placebo effect, in short, the phenomena of patients healing despite a treatment which is not expected to effect them. Homeopaths have responded to these criticisms with record of the treatment of children and animals, presumably not subject to placebo effect, and experiments on model organisms, plants, cell cultures in test tubes or other biological systems, which most definitely are not placebo susceptible.
Homeopathy has a very long history of evaluation in model organisms. While the primary data of Homeopathy have always been gathered in provings of substances on healthy individuals, many researchers have experimented with homeopathically prepared substances, and their effects on living organisms. The most interesting example of this work in the 19th century is that of Charles Darwin, (Many thanks to Dana Ullman for his excellent work on this subject, which is my primary source). Charles, having yet to write his famous book on evolution, was extremely ill, having failed to gain relief from convention treatment, sought care from Dr James Gully, a medically trained homeopath, whom also used hydrotherapy a great deal (in a therapeutic style that is suspiciously similar to modern Naturopathic medicine).
Darwin was not a great believer in Homeopathy, and was confounded by this recover for the rest of his life. He conducted one of the earlier series of experiments using model organisms, in his case the Drosera plant ( itself also a homeopathic remedy). In his experiments, Darwin was able to show a response by the Drosera plants to 1/20 millions of a grain of an ammonia salt. Darwin was enormously reticent to publish this information, fearing it would detract from the reception of his already contentious evolutionary theory.
Since this rather historically fascinating example, a large number of studies have been conducted. As a May 2018 review of the literature concluded, there were about 183 publications on the subject. Publications averaged about 2 per year from the 1970s-200s with a jump to about 5.5 per year afterwards. Furthermore quality of publications has markedly increased with 13% of publications high quality before 2000 compared to 44% afterwards.
One specific aspect of this research, is Homeopathic research on plant models. One review in 2015 found 157 studies, but that only 48 included adequate information to evaluate them. A second study done in 2018 found similar results. Several studies were replications, on successful, but 4 unsuccessful, with several possible variables identified.In general standardized procedures were recommended, including negative controls, and better control and identification of interference factors.
Research on abiotically stressed plants ( plants stressed by environmental conditions, instead of pathology) have also been accomplished, with reproducible and significant effects found, including effects beyond Avogadro’s number, although interestingly, one replication occurred generating opposite results. Again the authors stressed the need for replication and standardized procedures. A similar study on diseased plants as well was done in 2009. The authors as well found significant and reproducible effects of Homeopathic preparations on plant models, again beyond Avogadro’s number, though again standardized procedures are required, as is more replication.
Another fascinating body of work is the examination oh Homeopathic remedies through the medium of NMR. This method has, interestingly, been shown by several studies, to be able to detect differences between different Homeopathic potencies. In one recent study, changes in the emission from water was determined to be altered by both crude and ultramolecular homeopathic preparations in water. In another fascinating study, differing triturations of the same remedy at a different potency also displayed differing emission spectra. Another study examined triturated potencies of zincum metallicum in terms of their physical properties. Many properties were not altered, but did find that thermogravimetric and differential scanning calorimetry differed between homeopathically prepared and control samples.
The final say in this matter should perhaps be towards the greatest study on the subject, a 2015 literature review solely on replications in in vitro research in Homeopathy. This paper focused solely on experiments involving potencies diluted beyond Avogadro’s number, with no possible confounding by particles being present.Trials were classified as yielding either compatible results, no results, or opposite results. The null hypothesis of this trial was that no results was the default states, indicating no physiological effect. Of 126 studies found 98% were found to be replications, with 70.4% achieving comparable results, 20.4% obtaining opposite results, and 9.2% no results. With these results, the null hypothesis can be firmly rejected. In terms of raw numbers 28 experimental models were replicated, 24 with comparable results, 12 with no effect, and 6 with opposite effect. Five models were externally and independently replicated with comparable results.
Within this paper we can clearly see definite progress in the in vitro science of Homeopathy. A previous publication in 2007 found similar ( though lower numbers) of results, with a notation that both high quality trials do show effects and that no model was universally reproducible yet.
The issue of methodology looms large in this field of research. To understand this we will follow the ongoing and fascinating saga of one research model’s development, the Basophil model.
The Basophil model of research in Homeopathy began by accident, when a laboratory assistant of Jacque Benviniste, used a wrong (diluted) preparation of Immunoglobulin E, which caused a reaction ( degranulation) in the basophils it was administered to. Beneviniste noticed this phenomena, and began experimenting with it. He discovered that agitated dilutions performed better than simple dilutions, and this drew a strong parallel with Homeopathy, which was much more salient in French medicine than in North America. Beneviniste shared his research with 4 labs throughout the world, which managed to replicate the results.
Beneviniste published his paper in Nature, and it was accompanied by an unprecedented editorial, urging a suspension of judgement over the results, and distancing the editorial team from the research. Subsequently, the magician James Randi (who is not, despite his pretensions, a scientist), and John Maddox and fraud expert Walter Stuart. They, lacking expertise in the technique, in a very small number of attempts, failed to replicate the experiment, and concluded it was a fluke caused by sloppy methods or some other error, ignoring replication having already been done by several skilled teams throughout the world.
Several other teams attempted to replicate the findings, with mixed results. According to a lacture by Dr Peter Fischer, the experiments were replicated about 30% of the time. This was largely to do with the methodology. In Beneviniste’s methods, homeopathic style preparations of Immunoglobulin E were prepared and administered to cultures of basophils. When basophils come into contact with Immunoglobulin E, degranulation is the result. At differing dilutions of Immunoglobulin E, differing rates of degranulation were observed in some cultures, including those beyond avogadro’s number. Numerous factors appeared to be involved in whether basophils degranulated, resulting in the lower 30% reproduction rate.
Not that none of this subtlety in research methodology has ever been reported in the conventional media. Nor has the many replications been mentioned. Beneviniste is still cited as a fraud by many on the basis of a single experiment by non scientists, despite repeated ( though low) replication by other skilled scientists. As I have repeatedly shown (here and here) many organizations opposed to Naturopathic medicine and Homeopathy will use a number of fake news tactics to discredit therapies, despite often very good science in support of them.
Benevinistes model was later modified. As in actual clinical practice, where only people in certain pathological states were found to respond to a remedy, it was found that basophils responded to Homeopathic preparations when in a certain pathological state. Basophils here hence sensitized to pathological stimuli, then exposed to homeopathic dilutions of histamine, and then exposed to an antigen. The percentage of basophils that degranulated was measured, and found to be lesser in the group treated with Homeopathic histamine. This response did vary with the homeopathic potency of histamine administered, with a bell curve style peak from 15-17C. The main paper with this updated model was published in the journal Homeopathy in 2009.
The advantage of this more complex procedure using presensitization was a procedure which was much more consistent in terms of replication. This model has been replicated repeatedly, one such published replication can be found here. The procedure was, in 2009, replicated by 4 independent laboratories. This number has likely increased considerably in the 9 years since. According to a lecture by Dr. Fisher, this model was about 60% replicable, having far fewer variables influencing results.
The latest methods in this field are achieving consistent and reproducible effects using sensitized organisms, a phenomena that parallels clinical observation in Homeopathy. Interestingly this body of research has confirmed one clinical observation of Homeopathy seen for decades, that of a bell curve. Organisms tend to respond to only a certain range of potentiates, and both higher and lower potencies than their range will produce no results.
This is in strong contrast to the conventional model of pharmacology, which has found S shaped curves far more typically when observing physiological responses to drugs. Drugs, when administered to a responsive system, typically have a threshold below which they have no activity, followed by a phase in which small increases or decreases in concentrations of a drug cause massive changes in activity, followed by a plateau in which the effects of a drug do not increase very much, compared with the rapid phase. These two curves are displayed in the figure to the right. S curves are shown in blue, and bell curves in red.
This contrast has fascinating ramifications. The first being that Homeopathic medicines do not act like crude drugs, that there is a fundamental activity, profoundly based on the amount of potentisation and triturations, that exerts a physiological effect on the body, independent of chemical constituents. This implies a number of factors playing into biology that have very little understanding within modern biology. A number of profound biological and medical discoveries await for those brave enough to explore the implications of these data.
In the face of this large amount of research, arguments that Homeopathy has no effect are not sustainable. Those who make such arguments are either ignorant, or are deliberately being deceptive.
To summarize, an available research presentation on the latest Homeopathy research is given below.
Thank you for reading!
Image Credit: https://commons.wikimedia.org/wiki/File:Funci%C3%B3n_sigmoide_02.svg